Understanding how a blood protein affects blood vessel health in diabetes
The role of hemoglobin alpha in diabetes-related vascular dysfunction
This project looks at how high blood sugar in diabetes changes a protein called hemoglobin alpha in blood vessel linings, which might lead to problems with circulation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-11132671 on NIH RePORTER |
What this research studies
When you have diabetes, high blood sugar can change proteins in your body, including a form of hemoglobin found in the lining of your blood vessels. This research explores how these changes to hemoglobin alpha might affect how your blood vessels work and contribute to common diabetes complications. We want to understand if this altered protein causes blood vessels to function improperly. By learning more about this process, we hope to find new ways to protect blood vessel health for people with diabetes.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients, but its findings could eventually benefit individuals living with diabetes who experience or are at risk for vascular complications.
Not a fit: Patients without diabetes or those whose conditions are unrelated to blood vessel dysfunction in diabetes would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could uncover new ways to prevent or treat blood vessel damage, a common and serious complication for people with diabetes.
How similar studies have performed: While the role of hemoglobin alpha in blood vessel cells is a relatively new area of focus, other studies have shown that high blood sugar can indeed alter proteins and contribute to diabetes complications.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Bagher, Pooneh — University of Nebraska Medical Center
- Study coordinator: Bagher, Pooneh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.