Understanding how a beneficial gut bacterium helps colonize the gut.
Control of gut colonization by the prominent gut bacterium Bacteroides thetaiotaomicron
This study is looking at how a friendly gut bacterium called Bacteroides thetaiotaomicron settles in our intestines, focusing on special proteins that help it thrive by interacting with sugars in our food, which could lead to better understanding of gut health and how to support good bacteria.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11042703 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the gut bacterium Bacteroides thetaiotaomicron colonizes the mammalian gut, focusing on specific proteins that facilitate this process. The study will explore the unique properties of these proteins and how they interact with sugars in the diet to influence bacterial growth and colonization. By examining the biochemical activities of these proteins and their regulatory roles, the research aims to uncover new insights into gut health and the factors that promote the presence of beneficial bacteria.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in improving their gut health, particularly those with conditions related to gut microbiota imbalance.
Not a fit: Patients with established gut disorders that are not influenced by bacterial colonization may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing gut health and preventing conditions associated with gut dysbiosis.
How similar studies have performed: Previous research has shown that understanding gut microbiota interactions can lead to significant advancements in gut health, indicating potential success for this approach.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Groisman, Eduardo — Yale University
- Study coordinator: Groisman, Eduardo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.