Understanding how a bacterial toxin affects host cell survival
Host Responses to the Pore-Forming Toxin Listeriolysin O
This study looks at how a toxin from the Listeria bacteria affects our cells during an infection and aims to find ways to help those cells survive, which could lead to better treatments for people with listeriosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11042232 on NIH RePORTER |
What this research studies
This research investigates how the pore-forming toxin Listeriolysin O (LLO) from the bacterium Listeria monocytogenes impacts host cells during infection. The study aims to uncover the mechanisms that allow infected cells to survive despite damage to their membranes caused by LLO. By exploring the role of specific host proteins and calcium signaling in cell viability, the research seeks to identify potential therapeutic targets for improving outcomes in listeriosis. Patients may benefit from insights gained into how to enhance immune responses or develop new treatments against infections caused by this pathogen.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals at risk for listeriosis, such as pregnant women, the elderly, and immunocompromised patients.
Not a fit: Patients with non-infectious conditions or those not at risk for listeriosis may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating or preventing infections caused by Listeria monocytogenes.
How similar studies have performed: Other research has shown success in understanding bacterial toxins and their interactions with host cells, indicating that this approach has potential for meaningful discoveries.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Seveau, Stephanie M M — Ohio State University
- Study coordinator: Seveau, Stephanie M M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.