Understanding how a bacterial protein helps grow insulin-producing cells
Official title: Investigating the Molecular Mechanisms of Beta-Cell Expansion Factor A-induced Beta-Cell Proliferation
Funded at University of Oregon · NIH-11071851 · Data updated 2026-11-12
This study is looking at how a special protein from bacteria can help grow and develop the insulin-producing cells in the pancreas, which could lead to better treatments for diabetes.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oregon NIH-funded |
| Lab location | 1 site (Eugene, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $49,319 |
| NIH project number | 1F31DK141197-01A1 |
| Project ID | NIH-11071851 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with type I or type II diabetes who may benefit from advancements in beta-cell regeneration therapies.
✕Less likely to help
Patients who do not have diabetes or related metabolic disorders may not receive any benefit from this research.
What this research studies
This research investigates how a bacterial protein called Beta-Cell Expansion Factor A (BefA) can stimulate the growth and maturation of insulin-producing beta-cells in the pancreas. By using advanced imaging techniques and genetic manipulation in zebrafish and human stem cells, the study aims to uncover the molecular mechanisms behind BefA's effects on these cells. The ultimate goal is to enhance our understanding of beta-cell proliferation, which could lead to new treatments for diabetes. Patients may benefit from insights that could improve the generation of insulin-producing cells for diabetes therapy.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that enhance the production of insulin-producing cells, offering new hope for diabetes patients.
How similar studies have gone: Previous research has shown promise in using similar approaches to enhance beta-cell function and proliferation, indicating potential for success in this area.
Where this research is happening
-
University of Oregon
Eugene, United States Active
Researchers
- Principal investigator: Horve, Patrick — University of Oregon
- Study coordinator: Horve, Patrick
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.