Understanding how a bacterial protein affects immune response and disease
Official title: Defining the role of the Brucella TIR-NAD hydrolase activity in immunosuppression and pathogenesis
Funded at University of Wisconsin-Madison · NIH-11114798 · Data updated 2026-11-12
This study is looking at a protein from the Brucella bacteria to see how it affects the immune system and might make it harder for your body to fight off infections, with the hope of finding better ways to manage or treat these infections.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | April 24, 2025 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $233,250 |
| NIH project number | 1R21AI190247-01 |
| Project ID | NIH-11114798 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been diagnosed with Brucella infections or are at risk of such infections.
✕Less likely to help
Patients who do not have Brucella infections or related conditions may not benefit from this research.
What this research studies
This research investigates how a specific protein from the Brucella bacteria influences the immune system and contributes to disease. The study focuses on the protein's ability to break down a crucial molecule in host cells, which may weaken the immune response during infection. By examining how this protein interacts with immune cells, researchers aim to uncover its role in bacterial virulence. The findings could lead to new insights into how infections can be better managed or treated.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating infections caused by Brucella and potentially other pathogens.
How similar studies have gone: Other research has shown promising results in understanding bacterial interactions with the immune system, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Salcedo, Suzana P — University of Wisconsin-Madison
- Study coordinator: Salcedo, Suzana P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.