Understanding how a bacteria causes severe infections
Proteolytic regulation of the Streptococcus pyogenes cell surface
['FUNDING_R01'] · EMORY UNIVERSITY · NIH-10997428
This study is looking at how a common bacteria called Streptococcus pyogenes causes serious illnesses like strep throat and skin infections, with the goal of finding new ways to help treat these conditions by understanding how the bacteria trick our immune system.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-10997428 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which Streptococcus pyogenes, a common bacterial pathogen, causes severe diseases such as strep throat, necrotizing fasciitis, and acute rheumatic fever. The team aims to identify specific proteins that the bacteria use to manipulate the host's immune response, which could lead to more effective treatments. By studying the interactions between bacterial proteins and host cells, the researchers hope to uncover new therapeutic targets that can mitigate the harmful effects of these infections.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from severe infections caused by Streptococcus pyogenes, particularly children with acute pharyngitis or those at risk for invasive diseases.
Not a fit: Patients with infections caused by other types of bacteria or those who do not have severe manifestations of Streptococcus pyogenes infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments that reduce the severity of infections caused by Streptococcus pyogenes.
How similar studies have performed: Previous research has shown promise in understanding bacterial pathogenesis and developing targeted therapies, suggesting that this approach could yield significant insights.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LAROCK, CHRISTOPHER N — EMORY UNIVERSITY
- Study coordinator: LAROCK, CHRISTOPHER N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: bacterial bloodstream infection