Understanding how a bacteria causes chronic stomach infections
Official title: How ribosomal silencing promotes chronic infection of the gastric pathogen Helicobacter pylori
Funded at University of California Santa Cruz · NIH-10998526 · Data updated 2026-11-12
This study is looking into how the common stomach bacteria Helicobacter pylori can stick around and cause ongoing infections even after antibiotics, with the hope of finding better ways to help people who are dealing with these stubborn infections.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Santa Cruz NIH-funded |
| Lab location | 1 site (Santa Cruz, United States) |
| Project start | July 29, 2024 |
| Project end | July 28, 2025 |
| Funding year | 2024 |
| Award (this year) | $41,873 |
| NIH project number | 1F31AI176804-01A1 |
| Project ID | NIH-10998526 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been diagnosed with chronic H. pylori infections and have not responded to standard antibiotic therapies.
✕Less likely to help
Patients who do not have H. pylori infections or those who have successfully eradicated the bacteria will not benefit from this research.
What this research studies
This research investigates the mechanisms by which Helicobacter pylori, a common stomach bacteria, can persist in the body and cause chronic infections despite antibiotic treatment. The study focuses on how this bacteria forms biofilms and regulates its ribosome population in low-growth states, which may contribute to its ability to evade eradication. By examining these processes, the research aims to uncover fundamental insights that could lead to improved treatment strategies for patients suffering from chronic H. pylori infections.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for chronic H. pylori infections, reducing the risk of severe gastrointestinal diseases and cancers.
How similar studies have gone: Previous research has shown promise in understanding bacterial biofilms and their role in chronic infections, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of California Santa Cruz
Santa Cruz, United States Active
Researchers
- Principal investigator: Elshenawi, Yasmine — University of California Santa Cruz
- Study coordinator: Elshenawi, Yasmine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.