Understanding how 7SK RNA methylation affects non-small cell lung cancer
Official title: The molecular basis of 7SK RNA methylation in non-small cell lung cancer
Funded at University of Florida · NIH-11001170 · Data updated 2026-11-12
This study is looking at how changes in a specific RNA molecule called 7SK might affect the growth of non-small cell lung cancer (NSCLC) cells, with the hope of finding new ways to treat this type of lung cancer.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $213,881 |
| NIH project number | 5R21CA287107-02 |
| Project ID | NIH-11001170 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with non-small cell lung cancer.
✕Less likely to help
Patients with other types of lung cancer or those without a cancer diagnosis may not benefit from this research.
What this research studies
This research investigates the role of 7SK RNA methylation in non-small cell lung cancer (NSCLC), a common and deadly form of lung cancer. The study aims to identify specific molecular pathways and mechanisms by which the methylation of 7SK RNA influences cancer cell growth and gene expression. Using advanced techniques like real-time PCR and CRISPR, researchers will explore how modifying 7SK RNA can impact the behavior of NSCLC cells. This work could lead to a better understanding of NSCLC and potential new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for treating non-small cell lung cancer.
How similar studies have gone: Previous research has shown that targeting RNA modifications can be effective in cancer treatment, suggesting potential success for this approach.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Xie, Mingyi — University of Florida
- Study coordinator: Xie, Mingyi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.