Understanding how 7SK RNA interacts with HIV-1 proteins
Structural biology of 7SK RNP and its interaction with HIV-1 Tat
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-10837030
This study is looking at how a special RNA and its proteins work together to control gene activity and help the HIV virus replicate, which could lead to new ways to treat HIV.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10837030 on ClinicalTrials.gov |
What this research studies
This research investigates the structural biology of the 7SK ribonucleoprotein complex, which plays a crucial role in regulating the transcription of genes and the replication of HIV-1. By using advanced techniques such as NMR spectroscopy, X-ray crystallography, and cryo-electron microscopy, the study aims to uncover how the 7SK RNA and associated proteins assemble and interact with HIV-1 Tat, a key factor in HIV replication. The findings could provide insights into the mechanisms of HIV transcription and potentially lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV-1 who may benefit from advancements in treatment strategies.
Not a fit: Patients who are not infected with HIV-1 or those with other unrelated health conditions may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that inhibit HIV replication and improve outcomes for patients living with HIV.
How similar studies have performed: Other research has shown success in understanding viral interactions with host cellular mechanisms, indicating potential for breakthroughs in this area.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FEIGON, JULI — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: FEIGON, JULI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Disorder, Disease, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus