Understanding how 53BP1 affects DNA structure and cell function
Official title: 53BP1 regulates genome biology and cellular physiology through liquid phase separation
Funded at Case Western Reserve University · NIH-10919760 · Data updated 2026-11-12
This study is looking at how a protein called 53BP1 helps keep our DNA safe and organized, which is important for how our cells work, and it’s for anyone interested in understanding more about how our bodies manage genetic information.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 4, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $403,501 |
| NIH project number | 5R01GM148662-02 |
| Project ID | NIH-10919760 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions linked to DNA repair mechanisms or chromosomal abnormalities.
✕Less likely to help
Patients with conditions unrelated to DNA structure or cellular physiology may not benefit from this research.
What this research studies
This research investigates the role of a protein called 53BP1 in maintaining the integrity of a specific type of DNA structure known as heterochromatin, which is crucial for various cellular processes. The study focuses on how 53BP1 interacts with DNA through a process called liquid-liquid phase separation, where proteins and nucleotides form liquid droplets that help organize cellular functions. By exploring these mechanisms, the research aims to uncover new insights into how cells maintain their genetic information and respond to environmental changes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases related to DNA damage and cellular dysfunction.
How similar studies have gone: Other research has shown promising results in understanding the role of proteins in DNA repair and cellular organization, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Zhang, You-Wei — Case Western Reserve University
- Study coordinator: Zhang, You-Wei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.