Understanding how 53BP1 affects DNA structure and cell function
53BP1 regulates genome biology and cellular physiology through liquid phase separation
['FUNDING_R01'] · CASE WESTERN RESERVE UNIVERSITY · NIH-10919760
This study is looking at how a protein called 53BP1 helps keep our DNA safe and organized, which is important for how our cells work, and it’s for anyone interested in understanding more about how our bodies manage genetic information.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10919760 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a protein called 53BP1 in maintaining the integrity of a specific type of DNA structure known as heterochromatin, which is crucial for various cellular processes. The study focuses on how 53BP1 interacts with DNA through a process called liquid-liquid phase separation, where proteins and nucleotides form liquid droplets that help organize cellular functions. By exploring these mechanisms, the research aims to uncover new insights into how cells maintain their genetic information and respond to environmental changes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions linked to DNA repair mechanisms or chromosomal abnormalities.
Not a fit: Patients with conditions unrelated to DNA structure or cellular physiology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases related to DNA damage and cellular dysfunction.
How similar studies have performed: Other research has shown promising results in understanding the role of proteins in DNA repair and cellular organization, suggesting that this approach could yield valuable insights.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHANG, YOU-WEI — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: ZHANG, YOU-WEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.