Understanding how 3D structures of DNA affect cell behavior
Mechanisms and functions of three-dimensional chromatin structures in quiescent cells
['FUNDING_OTHER'] · COLORADO STATE UNIVERSITY · NIH-10939836
This study looks at how the way DNA is organized in cells affects important processes like gene regulation and DNA repair, using yeast as a model, to help us understand better how these mechanisms work in resting cells, which is important for things like stem cell health and cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLORADO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (FORT COLLINS, UNITED STATES) |
| Trial ID | NIH-10939836 on ClinicalTrials.gov |
What this research studies
This research investigates the three-dimensional organization of chromatin, which is crucial for regulating DNA processes in cells. By focusing on a model organism, budding yeast, the study aims to uncover how chromatin structures, specifically topologically associated domains (TADs), influence gene regulation, DNA replication, and repair. The researchers will employ advanced techniques such as high-resolution genomics and microscopy to explore these mechanisms in quiescent cells, which are in a resting state important for stem cell maintenance and cancer recurrence. The findings could provide insights into the fundamental processes that govern cell behavior and health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to stem cell function or cancer recurrence.
Not a fit: Patients with acute conditions unrelated to chromatin structure or cell cycle regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting cancer and improving stem cell therapies.
How similar studies have performed: Previous research has shown promising results in understanding chromatin structures, but this specific approach focusing on quiescent cells is relatively novel.
Where this research is happening
FORT COLLINS, UNITED STATES
- COLORADO STATE UNIVERSITY — FORT COLLINS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SWYGERT, SARAH GRACE — COLORADO STATE UNIVERSITY
- Study coordinator: SWYGERT, SARAH GRACE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers