Understanding how 3D structures in vascular cells relate to genetic risks for diseases.
Mapping, modeling, and manipulating 3D contacts in vascular cells to connect risk variants to disease genes
This study is looking at how certain genetic changes related to blood vessel diseases affect how genes work in our cells, and it aims to help patients understand their conditions better so that treatments can be more tailored to their needs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11046596 on NIH RePORTER |
What this research studies
This research investigates how noncoding genetic variants associated with vascular diseases influence gene expression through their 3D spatial arrangements in vascular cells. By utilizing advanced techniques like CRISPR and 3D genome mapping, the team aims to identify connections between these genetic variants and specific target genes. Patients may benefit from insights into the molecular mechanisms underlying their vascular conditions, potentially leading to more personalized treatment approaches.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of vascular diseases or those diagnosed with conditions like atherosclerosis.
Not a fit: Patients with non-vascular related genetic conditions or those without any known genetic predisposition to vascular diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with vascular diseases.
How similar studies have performed: Previous research has shown promise in using 3D genome mapping to connect genetic variants to disease mechanisms, indicating a potential for success in this approach.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Engreitz, Jesse M — Stanford University
- Study coordinator: Engreitz, Jesse M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.