Understanding how 3D genomic structures affect immune cells and allergic reactions
3-Dimensional genomic architecture in innate lymphoid cells and allergic inflammation
This study is looking at how certain immune cells work in our bodies to keep us healthy and how they react to allergens, which could help us understand why some people develop asthma and other allergies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11099889 on NIH RePORTER |
What this research studies
This research investigates the role of three types of immune cells, known as innate lymphoid cells (ILCs), in maintaining health and responding to allergens. By examining the 3D architecture of the genome and how it influences the development and function of these cells, the study aims to uncover mechanisms that lead to allergic airway inflammation. The researchers will utilize advanced techniques to analyze the interactions between DNA elements that regulate the expression of key genes involved in immune responses. This could provide insights into how dysregulation of these cells contributes to conditions like asthma and other allergic diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from asthma or other allergic conditions.
Not a fit: Patients with non-allergic respiratory conditions or those without immune system involvement may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating allergic diseases by targeting the underlying genetic mechanisms.
How similar studies have performed: Previous research has shown promising results in understanding immune cell functions through genomic studies, suggesting that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Henao-Mejia, Jorge — University of Pennsylvania
- Study coordinator: Henao-Mejia, Jorge
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.