Understanding how 3D genome structure affects prostate cancer development
3D genome architecture and the origins of recurrent genomic rearrangements in prostate cancer
This study is looking at how the structure of our DNA can change in ways that lead to prostate cancer, focusing on certain gene fusions, and aims to find better ways to diagnose and treat the disease for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10770418 on NIH RePORTER |
What this research studies
This research investigates the role of 3D genome architecture in the formation of genomic rearrangements that drive prostate cancer. By focusing on the fusion of specific genes, such as TMPRSS2 and ERG, the study aims to uncover the mechanisms behind these changes and their implications for cancer progression. The researchers will utilize advanced genomic techniques to analyze how androgen signaling and DNA topoisomerase II beta function contribute to genomic stability and cancer development. This work could lead to improved strategies for early diagnosis and targeted therapies for prostate cancer patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are men diagnosed with prostate cancer, particularly those with recurrent genomic rearrangements.
Not a fit: Patients with prostate cancer who do not exhibit genomic rearrangements or those with advanced metastatic disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention, early diagnosis, and targeted treatments for prostate cancer.
How similar studies have performed: Previous research has shown promising results in understanding genomic rearrangements in various cancers, indicating that this approach may yield valuable insights.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Mani, Ram Shankar — Ut Southwestern Medical Center
- Study coordinator: Mani, Ram Shankar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.