Understanding how 3D genome structure affects gene regulation in animals
Official title: Evolution of 3D Genome Folding Mechanisms and Gene Regulatory Strategies in Metazoans
Funded at University of Chicago · NIH-11117097 · Data updated 2026-11-12
This study looks at how the way our genes are folded in three dimensions affects how they work, and it’s for anyone interested in understanding more about genetic diseases and how they might be treated.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | July 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $401,296 |
| NIH project number | 5R35GM155159-02 |
| Project ID | NIH-11117097 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with genetic disorders or those interested in the genetic basis of diseases.
✕Less likely to help
Patients with conditions unrelated to genetic regulation or those not affected by genetic disorders may not receive benefit from this research.
What this research studies
This research investigates how the three-dimensional folding of the genome influences the regulation of genes in various animal species. By examining mechanisms like loop extrusion and phase separation, the study aims to uncover how these structural features impact gene transcription. The research utilizes advanced techniques to analyze genome folding in different animal models, including flies and mice, to understand evolutionary changes in gene regulation. Patients may benefit from insights gained into genetic diseases linked to gene regulation.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating genetic disorders by improving our understanding of gene regulation.
How similar studies have gone: Previous research has shown promising results in understanding genome folding and its implications for gene regulation, indicating that this approach has potential for significant findings.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Marlow, Heather a. — University of Chicago
- Study coordinator: Marlow, Heather a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.