Understanding how 3D genome structure affects gene regulation
Studying the function of human genetic variation in the light of 3D genome organization
This study is looking at how the 3D shape of our DNA affects how genes work, especially how different genetic variations can change this shape and influence gene activity, which could help us understand health issues better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | La Jolla Institute for Immunology NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11102425 on NIH RePORTER |
What this research studies
This research investigates the role of three-dimensional (3D) chromatin structure in regulating gene expression. It focuses on how genetic variations influence the organization of gene promoters and their subsequent expression. The approach combines advanced computational methods with biological data from a large number of donors, including genotype and gene expression profiles. By analyzing these relationships, the research aims to uncover new insights into gene regulation mechanisms that could impact various health conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with specific genetic variations that may influence immune cell function and gene expression.
Not a fit: Patients without significant genetic variations or those not affected by conditions related to gene regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for understanding and treating genetic diseases by targeting gene regulation mechanisms.
How similar studies have performed: Previous research has shown promising results in understanding gene regulation through chromatin structure, indicating that this approach has potential for significant discoveries.
Where this research is happening
La Jolla, United States
- La Jolla Institute for Immunology — La Jolla, United States (Active)
Researchers
- Principal investigator: Ay, Ferhat — La Jolla Institute for Immunology
- Study coordinator: Ay, Ferhat
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.