Understanding how 3D genome structure affects gene regulation
Sequence models of genome regulatory architecture in 3D
['FUNDING_OTHER'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11014636
This study is looking at how the way our genes are arranged in 3D space affects how they work, which could help us understand how genetic differences might lead to diseases and improve personalized treatments for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11014636 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between genome sequences and their regulatory functions by focusing on the three-dimensional architecture of the genome. By utilizing advanced computational models, the project aims to decode how variations in genetic sequences influence gene expression and regulation. The approach involves analyzing complex interactions within the genome, including how different regions of DNA communicate with each other in three-dimensional space. This could lead to better predictions of how genetic variations contribute to diseases and inform precision medicine.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or those interested in the genetic basis of their health conditions.
Not a fit: Patients with purely environmental health issues or those without any genetic component to their conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic diseases and improve personalized treatment strategies.
How similar studies have performed: Other research has shown promise in using computational models to understand genetic regulation, indicating that this approach could yield significant insights.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHOU, JIAN — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: ZHOU, JIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.