Understanding how 3D genome organization affects DNA repair in cancer cells
Official title: Maintenance of genome stability in 3D
Funded at Columbia University Health Sciences · NIH-10982014 · Data updated 2026-11-12
This study is looking at how the way DNA is organized in cancer cells affects how well it can repair itself after damage, with the hope of finding better ways to make chemotherapy work more effectively for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 3, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $541,682 |
| NIH project number | 1R01CA287287-01A1 |
| Project ID | NIH-10982014 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with cancers characterized by genomic instability who are undergoing or considering chemotherapy.
✕Less likely to help
Patients with stable tumors that do not exhibit genomic instability may not benefit from this research.
What this research studies
This research investigates how the three-dimensional arrangement of DNA within cells influences the repair of DNA damage, particularly in cancer cells. By examining the spatial organization of DNA repair processes, the study aims to uncover mechanisms that could enhance the effectiveness of chemotherapy. The researchers will explore how mechanical forces contribute to the formation of DNA repair domains and how these domains interact with DNA replication. This work could lead to new strategies for targeting vulnerabilities in cancer treatment.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer therapies by identifying new ways to enhance DNA repair mechanisms in cancer cells.
How similar studies have gone: Previous research has shown that understanding DNA repair mechanisms can significantly improve cancer treatment outcomes, indicating that this approach has potential for success.
Where this research is happening
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Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Gautier, Jean — Columbia University Health Sciences
- Study coordinator: Gautier, Jean
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.