Understanding how 3D genome organization affects cancer development
Official title: 3D genome reorganization drives cancer development
Funded at Yale University · NIH-11092308 · Data updated 2026-11-12
This study is looking at how the way our genes are organized in 3D space affects the growth of lung cancer, and it’s for anyone interested in understanding more about how cancer develops and what new treatments might be possible.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $695,122 |
| NIH project number | 5R01CA292936-02 |
| Project ID | NIH-11092308 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with lung adenocarcinoma or those at high risk for developing this type of cancer.
✕Less likely to help
Patients with cancers other than lung adenocarcinoma or those without any cancer diagnosis may not benefit from this research.
What this research studies
This research investigates the role of three-dimensional (3D) genome organization in cancer progression, particularly focusing on lung adenocarcinoma. By utilizing advanced imaging techniques, the study aims to create a detailed atlas of genome structures in individual cancer cells, allowing researchers to observe how these structures change from normal to preinvasive and invasive stages of cancer. The approach involves a novel method called chromatin tracing, which provides insights into the specific alterations in genome organization that may drive tumor development. This research could lead to a better understanding of cancer biology and potential new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in cancer treatment by identifying new biomarkers and therapeutic targets based on genome organization.
How similar studies have gone: Previous studies using 3D genomics technologies have shown promising results in understanding cancer biology, suggesting that this approach has the potential for significant advancements.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Muzumdar, Mandar Deepak — Yale University
- Study coordinator: Muzumdar, Mandar Deepak
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.