Understanding how 3D chromatin structure affects gene regulation
Joint analysis of 3D chromatin organization and 1D epigenome
This study is looking at how the way our DNA is organized in 3D space affects how genes are turned on and off in different types of cells, using smart computer techniques to help us understand this better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10886002 on NIH RePORTER |
What this research studies
This research investigates the relationship between the three-dimensional organization of chromatin and the one-dimensional epigenome across different cell types. By utilizing advanced deep learning techniques, the project aims to analyze how these genomic elements are spatially arranged within the nucleus and how this arrangement influences gene transcription. The study will address challenges related to the resolution differences in chromatin data and aims to develop new computational methods for genome annotation that incorporate 3D structural information. This could lead to a better understanding of the mechanisms that regulate gene expression over long genomic distances.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions influenced by epigenetic factors, such as certain cancers or genetic disorders.
Not a fit: Patients with conditions unrelated to chromatin organization or epigenetic regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide insights into the fundamental mechanisms of gene regulation, potentially leading to new therapeutic strategies for diseases linked to epigenetic changes.
How similar studies have performed: Other research has shown success in analyzing chromatin organization and epigenetic regulation, indicating that this approach has potential for meaningful advancements.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Liu, Jie — University of Michigan at Ann Arbor
- Study coordinator: Liu, Jie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.