Understanding HIV's Effects in the Brain of People with HIV
In situ spatial characterization of CNS HIV-host cellular interactions from victims of sudden death
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11195691
This project looks closely at brain tissue from people with HIV to understand how the virus affects the brain, especially when methamphetamine use is also present.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11195691 on ClinicalTrials.gov |
What this research studies
For people living with HIV, the virus can hide in the brain, causing inflammation and damage, particularly when methamphetamine use is also involved. We don't fully understand how HIV-infected cells interact with brain tissue in these situations, especially for those on antiretroviral therapy (ART). This project uses a unique collection of brain samples from people with HIV who passed away suddenly, many of whom were on ART. By examining these samples, we hope to learn more about how HIV persists in the brain and contributes to neuroinflammation.
Who could benefit from this research
Good fit: This project primarily benefits people with HIV by advancing scientific knowledge, and it relies on post-mortem brain tissue donations from individuals with HIV who experienced sudden death.
Not a fit: Patients who are currently living and seeking direct treatment or intervention would not directly participate in this post-mortem tissue analysis.
Why it matters
Potential benefit: This research could lead to a better understanding of HIV's impact on the brain, potentially guiding future treatments for HIV-related brain inflammation and damage, especially for those who also use methamphetamine.
How similar studies have performed: This project utilizes a unique and extensive post-mortem tissue bank, making it a novel resource for in-depth spatial analysis of HIV infection in the brain.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HENRICH, TIMOTHY JENSEN — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: HENRICH, TIMOTHY JENSEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome, Acquired Immunodeficiency Syndrome Virus, Acquired brain injury