Understanding HIV in Brain Cells and Benzodiazepines
Benzodiazepine mediated mechanisms of transcriptional semi-quiescence in discrete myeloid populations
This project looks at how HIV hides in certain brain cells, especially in people who use benzodiazepine medications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Drexel University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11094897 on NIH RePORTER |
What this research studies
HIV can hide in specific brain cells, like perivascular macrophages and microglia, forming "reservoirs" that current HIV medications can't reach. These hidden viruses can cause brain inflammation and potentially reactivate if treatment is stopped or fails. We don't fully understand how HIV stays hidden in these brain cells. This work aims to uncover the genetic switches that keep HIV quiet in these cells, particularly considering how benzodiazepine use might affect this process.
Who could benefit from this research
Good fit: This research is relevant for people living with HIV, particularly those who have HIV in their central nervous system or use benzodiazepine medications.
Not a fit: Patients without HIV or those not using benzodiazepines may not directly benefit from this specific line of inquiry.
Why it matters
Potential benefit: Successfully understanding these hidden HIV reservoirs could lead to new ways to eliminate the virus from the brain, improving outcomes for people living with HIV.
How similar studies have performed: This research addresses a critical gap in understanding HIV reservoirs in the brain, especially concerning benzodiazepine use, suggesting a novel approach.
Where this research is happening
Philadelphia, United States
- Drexel University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Gaskill, Peter Jesse — Drexel University
- Study coordinator: Gaskill, Peter Jesse
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.