Understanding HIV evolution and latency in subtype C infections
Evolution and Latency of T-Tropic and M-Tropic HIV in People Infected with Subtype C
['FUNDING_R01'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-11085565
This study is looking at how HIV-1 subtype C changes and hides in the body, especially in the brain, to help us understand how it can lead to issues like dementia, with the goal of finding better treatments for people living with this type of HIV.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-11085565 on ClinicalTrials.gov |
What this research studies
This research investigates how HIV-1 subtype C evolves and establishes latency, particularly focusing on its impact within the central nervous system (CNS). By utilizing a unique collection of autopsy tissue samples and advanced cell culture models, the study aims to uncover the mechanisms behind the virus's behavior and its interactions with different cell types. Patients infected with subtype C HIV will be studied to gain insights into the virus's evolution and its potential to cause complications like dementia. The findings could lead to improved treatment strategies for those affected by this subtype.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals infected with HIV-1 subtype C, especially those experiencing neurological symptoms or complications.
Not a fit: Patients with HIV-1 infections from other subtypes or those without neurological complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of HIV-related complications, particularly in patients with subtype C infections.
How similar studies have performed: Previous studies on HIV-1 subtype B have shown significant insights, but research on subtype C is less explored, making this approach relatively novel.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SWANSTROM, RONALD I — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: SWANSTROM, RONALD I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome related dementia, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus