Understanding HIV and HBV co-infection using a monkey model
A Rhesus Macaque Model of HIV and HBV co-infection
This study is looking at how HIV and hepatitis B virus (HBV) work together in the body using monkeys to help us understand how these infections can cause serious health problems, so we can find better ways to treat people who have both.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11045600 on NIH RePORTER |
What this research studies
This research investigates the co-infection of HIV and HBV, two major global health concerns, using a rhesus macaque model. The study aims to develop a robust animal model that mimics the complexities of human co-infection, which is crucial for understanding the mechanisms that lead to severe health complications like liver dysfunction and fibrosis. By examining how these viruses interact within this model, researchers hope to uncover insights that could lead to better treatment strategies for affected individuals. The approach involves monitoring the progression of both infections and their impact on the immune system and liver health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are co-infected with HIV and HBV, particularly those experiencing complications related to liver health.
Not a fit: Patients who are solely infected with either HIV or HBV without co-infection may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients suffering from HIV and HBV co-infection.
How similar studies have performed: While there have been various studies on HIV and HBV separately, this specific approach using a rhesus macaque model for co-infection is novel and has not been extensively tested.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Burwitz, Benjamin J — Oregon Health & Science University
- Study coordinator: Burwitz, Benjamin J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.