Understanding HIV-1 reservoirs and their impact on health outcomes
Characterization of Non-subtype B HIV-1 Reservoirs and its Association with Longitudinal Clinical Outcomes
This study is looking at the hidden spots where HIV-1 can still hide in people who are on treatment, to better understand how these spots affect long-term health and to find new ways to improve treatment and possibly get rid of the virus altogether, and we’d love for patients to help by sharing their samples and information.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11080357 on NIH RePORTER |
What this research studies
This research investigates the hidden reservoirs of HIV-1 that persist in patients even when viral replication is controlled by antiretroviral therapy. It aims to characterize these reservoirs and understand their relationship with long-term health outcomes in individuals living with HIV. By analyzing the genetic diversity of the virus and the mechanisms that allow it to persist, the study seeks to uncover new strategies for improving treatment and potentially eradicating the virus. Patients may be involved in providing samples and data to help advance this important work.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy and have maintained viral suppression.
Not a fit: Patients who are not living with HIV or those who are not on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that may help eliminate HIV reservoirs and reduce the risk of viral rebound.
How similar studies have performed: Previous research has shown promise in understanding HIV reservoirs, but this specific approach may provide novel insights into their characteristics and implications for treatment.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Lee, Guinevere — Weill Medical Coll of Cornell Univ
- Study coordinator: Lee, Guinevere
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.