Understanding HIV-1 reservoir cells to improve treatment options
Official title: Single-cell Proteogenomic profiling of HIV-1 reservoir cells
Funded at Brigham and Women's Hospital · NIH-11044042 · Data updated 2026-11-12
This study is looking at a special type of immune cell that keeps HIV hidden in the body, and it aims to find out how these cells avoid being attacked by the immune system so that we can develop better treatments for people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | March 20, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,089,140 |
| NIH project number | 5R01AI176579-03 |
| Project ID | NIH-11044042 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who have a detectable viral reservoir and are undergoing antiretroviral therapy.
✕Less likely to help
Patients who are not living with HIV or those who have achieved complete viral suppression without any detectable reservoir may not benefit from this research.
What this research studies
This research investigates a specific group of CD4 T cells that harbor HIV-1 DNA and persist in the body, posing a challenge to curing HIV-1 infection. By utilizing advanced single-cell proteogenomic profiling techniques, the study aims to uncover how these cells can evade the immune system and identify their vulnerabilities. The goal is to better understand the characteristics of these reservoir cells, which may lead to new strategies for targeting them and improving treatment outcomes for individuals living with HIV.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments that help eliminate HIV-1 reservoir cells, potentially paving the way for a cure.
How similar studies have gone: Previous studies utilizing single-cell analysis have shown promise in understanding HIV-1 reservoirs, indicating that this approach may yield valuable insights.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Lichterfeld, Mathias — Brigham and Women's Hospital
- Study coordinator: Lichterfeld, Mathias
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.