Understanding high blood pressure after preeclampsia
Official title: Mechanisms of post-preeclampsia hypertension
Funded at Yale University · NIH-11015060 · Data updated 2026-11-12
This study is looking at how having preeclampsia during pregnancy might affect women's blood pressure and heart health later on, especially focusing on certain immune cells that could play a role in these changes, with the goal of finding better ways to help women who are at risk of high blood pressure after preeclampsia.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $249,000 |
| NIH project number | 5R00HL161321-04 |
| Project ID | NIH-11015060 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women who have experienced preeclampsia during pregnancy and are concerned about their long-term cardiovascular health.
✕Less likely to help
Patients who have not experienced preeclampsia or those with unrelated hypertension conditions may not benefit from this research.
What this research studies
This research investigates the long-term effects of preeclampsia on women's blood pressure and vascular health after pregnancy. It focuses on how certain immune cells, specifically T cells, may contribute to persistent hypertension and vascular changes that occur in women who have experienced preeclampsia. By using animal models, the study aims to uncover the mechanisms behind these changes and identify potential targets for treatment. The findings could lead to better management strategies for women at risk of hypertension following preeclampsia.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive measures for women at risk of hypertension after preeclampsia.
How similar studies have gone: Previous research has shown that immune responses play a role in hypertension, suggesting that this approach may yield valuable insights, although the specific mechanisms in post-preeclampsia hypertension are still being explored.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Biwer, Lauren Alysse — Yale University
- Study coordinator: Biwer, Lauren Alysse
Related research
Other NIH-funded projects on the same topics.
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Dynamic risk prediction and subtyping of hypertensive disorders in pregnancy
A digital health approach uses AI to spot early warning signs of preeclampsia and gestational hypertension from pregnancy data, so clinicians can tailor care for pregnant people.
-
Understanding how genes and environment interact to cause preeclampsia and later high blood pressure in mothers
This project looks at why some pregnancies develop preeclampsia and how it relates to long-term blood pressure and heart health in mothers.
-
AI-powered low-cost ultrasound to detect high-risk pregnancy conditions
A new, affordable ultrasound AI system helps frontline workers identify pregnancy complications like high blood pressure, preeclampsia, and restricted fetal growth.
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Children's long-term health after treating chronic hypertension in pregnancy
This grant studies how giving antihypertensive medicine during pregnancy for women with chronic high blood pressure affects their children’s health as they grow up.
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Reducing chronic high blood pressure after preeclampsia to protect heart and vessels
A randomized trial tests whether more intensive blood pressure control in the weeks after giving birth can lower long-term high blood pressure and improve blood vessel health in women who had a hypertensive pregnancy.
-
Gestational hypertension and preeclampsia: better blood pressure targets before delivery
This study tests whether keeping blood pressure under 140/90 mmHg (instead of 160/110) during pregnancy with high blood pressure improves outcomes for mothers and babies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.