Understanding HIF2alpha in Colon Cancer
The role of HIF2alpha in colon carcinogenesis
This research explores how inflammation and specific cell signals contribute to colon cancer growth, aiming to find new ways to help patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11099729 on NIH RePORTER |
What this research studies
Colon cancer is a serious health concern, and this project focuses on how inflammation plays a key part in its development and spread. We are looking closely at a specific protein called HIF2alpha, which seems to promote colon cancer growth by recruiting certain immune cells called neutrophils. Our work also considers how gut bacteria and their byproducts might influence HIF2alpha, and whether targeting this protein could lead to new treatments. By understanding these connections, we hope to uncover new strategies to fight colon cancer.
Who could benefit from this research
Good fit: This foundational research is for anyone interested in the underlying causes of colon cancer and future treatment options.
Not a fit: Patients seeking immediate treatment options may not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies and targeted treatments for colon cancer patients.
How similar studies have performed: This area of research is underexplored, suggesting a novel approach with the potential to generate new therapies.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Shah, Yatrik M — University of Michigan at Ann Arbor
- Study coordinator: Shah, Yatrik M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.