Understanding hidden RNA changes in human diseases
Computational approaches to delineate non-canonical splicing events
This research creates new computer tools to find and understand unusual changes in RNA that might be linked to many health conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11083619 on NIH RePORTER |
What this research studies
Our bodies rely on RNA splicing to create many different proteins, but sometimes these processes go wrong and contribute to various diseases. While some common RNA changes are well-known, new technologies are revealing previously hidden or 'non-canonical' changes that we don't yet fully understand. This project aims to build special computer programs to identify these emerging RNA patterns, explore their genetic roots using detailed sequencing data, and discover how they impact our health at the protein level. By uncovering these overlooked RNA variations, we hope to gain a deeper understanding of complex human diseases.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but focuses on understanding the underlying biological mechanisms of human diseases.
Not a fit: Patients seeking immediate treatment options or direct clinical interventions would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of how certain diseases develop, potentially paving the way for new diagnostic methods or treatments.
How similar studies have performed: This project is innovative in developing unique computational frameworks for previously understudied splicing events, building upon existing knowledge of more common RNA splicing patterns.
Where this research is happening
Chicago, United States
- Northwestern University — Chicago, United States (Active)
Researchers
- Principal investigator: Yang, Rendong — Northwestern University
- Study coordinator: Yang, Rendong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.