Understanding Hidden Genetic Instructions in Human Cells
Translation of overprinted non-canonical open reading frames from alternative transcript variants
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11163327
This project explores how human cells read hidden genetic messages within our DNA that can create new, small proteins.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11163327 on ClinicalTrials.gov |
What this research studies
Our genes contain instructions for making proteins, but sometimes there are hidden messages called internal open reading frames (iORFs) that create entirely different, smaller proteins. While these overlapping genetic instructions are common in viruses, we are just beginning to understand their widespread role in human cells. This research aims to discover how many of these hidden genetic messages exist and how they are expressed. We also want to learn if these newly found small proteins have important jobs, especially in processes like cell survival.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but future studies building on this knowledge may seek individuals with conditions related to cell growth or death.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: Understanding these hidden genetic instructions could lead to new ways to understand and potentially treat diseases where cell processes like growth and death are disrupted.
How similar studies have performed: While overlapping genes are well-known in viruses, their widespread existence and function in human cells are a relatively new and exciting area of discovery.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SLAVOFF, SARAH ANN — YALE UNIVERSITY
- Study coordinator: SLAVOFF, SARAH ANN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.