Understanding hidden cellular components and their roles in diseases like ALS
Illuminating cellular dark matter through the development of novel chemical tools
This study is looking at some little-known parts of our cells to understand how they work, especially in relation to ALS, and it aims to create new tools to see and change these parts in living cells to learn more about the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11093247 on NIH RePORTER |
What this research studies
This research focuses on uncovering the functions of previously uncharacterized cellular components, referred to as 'dark matter.' The team will develop innovative chemical tools to modify RNA and study its interactions with proteins, particularly in the context of amyotrophic lateral sclerosis (ALS). By creating methods to visualize and manipulate these components in live cells, the research aims to shed light on the molecular mechanisms that contribute to disease. Additionally, the project will explore the synthesis of specific lipid molecules within cells to understand their impact on cellular behavior.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with genetic forms of amyotrophic lateral sclerosis, particularly those with C9orf72 mutations.
Not a fit: Patients with non-genetic forms of ALS or other unrelated neurological disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapeutic strategies for treating ALS and other related diseases.
How similar studies have performed: While the approach of studying cellular 'dark matter' is innovative, similar methodologies in RNA and lipid research have shown promise in other contexts.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Devaraj, Neal Krishna — University of California, San Diego
- Study coordinator: Devaraj, Neal Krishna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.