Understanding hidden cellular components and their roles in diseases like ALS
Illuminating cellular dark matter through the development of novel chemical tools
This study is exploring some little-known parts of our cells to understand how they work with RNA and proteins in ALS, with the hope of finding new ways to understand the disease and its genetic links.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10898811 on NIH RePORTER |
What this research studies
This research focuses on uncovering the functions of previously uncharacterized cellular components, referred to as 'dark matter.' The team will develop innovative chemical tools to modify RNA and study its interactions with proteins, particularly in the context of amyotrophic lateral sclerosis (ALS). By creating methods to visualize and manipulate these components in live cells, the research aims to shed light on the molecular mechanisms that contribute to disease. This could lead to a better understanding of how certain genetic factors, such as the C9orf72 repeat expansion, influence ALS pathology.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with amyotrophic lateral sclerosis, particularly those with genetic factors related to the C9orf72 mutation.
Not a fit: Patients with other neurological disorders unrelated to ALS or those without genetic predispositions to the conditions being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential treatments for patients with amyotrophic lateral sclerosis.
How similar studies have performed: Other research has shown promise in using chemical tools to study cellular components, suggesting that this approach could yield valuable insights into ALS and similar conditions.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Devaraj, Neal Krishna — University of California, San Diego
- Study coordinator: Devaraj, Neal Krishna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.