Understanding Heart Valve Formation and Myxomatous Valve Disease
Role of the Epicardium in Valve Development and Valve Disease
['FUNDING_R01'] · MEDICAL UNIVERSITY OF SOUTH CAROLINA · NIH-11046517
This project explores how specific heart cells contribute to valve formation and how problems with these cells might lead to a condition called myxomatous valve disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDICAL UNIVERSITY OF SOUTH CAROLINA (nih funded) |
| Locations | 1 site (CHARLESTON, UNITED STATES) |
| Trial ID | NIH-11046517 on ClinicalTrials.gov |
What this research studies
We are looking at special cells called epicardially-derived cells (EPDCs) and their role in building the heart's atrioventricular (AV) valves. Our goal is to understand how these cells move and develop into the valve leaflets. We are also investigating if issues with these cells contribute to myxomatous valve disease, a condition that affects heart valves. Previous work in mouse models showed that changes in a specific signaling pathway or a transcription factor in these cells led to valve abnormalities similar to those seen in patients. This research aims to uncover the exact mechanisms regulating these processes and their connection to mitral valve disease.
Who could benefit from this research
Good fit: Patients with myxomatous valve disease or those with a family history of heart valve conditions might find this foundational research relevant to their health.
Not a fit: Patients with heart conditions unrelated to valve development or myxomatous valve disease may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of how heart valves form and why myxomatous valve disease develops, potentially opening doors for new ways to prevent or treat this condition.
How similar studies have performed: Previous studies by this team have shown initial success in identifying specific cell types and genetic pathways involved in valve development and disease in animal models.
Where this research is happening
CHARLESTON, UNITED STATES
- MEDICAL UNIVERSITY OF SOUTH CAROLINA — CHARLESTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WESSELS, ARNO — MEDICAL UNIVERSITY OF SOUTH CAROLINA
- Study coordinator: WESSELS, ARNO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Barlows Syndrome