Understanding heart tissue that is injured but not dead after ischemia
The identification and pathophysiology of non-infarcted but injured myocardium in the post-ischemic heart
This study is looking at a part of the heart that gets hurt but isn't completely damaged after a lack of blood flow, to better understand how it affects heart problems and irregular heartbeats, which could help doctors give better advice to patients with heart issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10757732 on NIH RePORTER |
What this research studies
This research investigates a specific area of the heart known as the intermediate zone, which is injured but not infarcted following ischemia. Using advanced imaging techniques, the study aims to map this zone and understand its unique characteristics and how it contributes to heart dysfunction and arrhythmias. By analyzing how different cell types survive in this area, the research seeks to uncover the underlying mechanisms of cardiac impairment and the risk of arrhythmias. This could lead to improved prognostic assessments for patients with heart conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients who have experienced ischemic heart disease and exhibit signs of cardiac impairment without having suffered a full infarction.
Not a fit: Patients with non-ischemic heart conditions or those who have already experienced significant heart failure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new insights into heart health and lead to better management strategies for patients with cardiac arrhythmias.
How similar studies have performed: While the investigation of the intermediate zone is relatively novel, similar approaches in cardiac research have shown promise in understanding heart tissue dynamics.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Zhao, Ming — Northwestern University at Chicago
- Study coordinator: Zhao, Ming
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.