Understanding heart swelling after blood flow restoration
Official title: Ischemia/Reperfusion injury and Myocardial edema
Funded at Yale University · NIH-10869983 · Data updated 2026-11-12
This study is looking at how swelling in the heart after a heart attack can cause damage, and it's testing new medications that might help reduce that swelling to improve recovery for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $645,489 |
| NIH project number | 5R01HL169520-02 |
| Project ID | NIH-10869983 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who have experienced an acute myocardial infarction or similar heart conditions.
✕Less likely to help
Patients with chronic heart conditions unrelated to ischemia or those who have not experienced a recent heart attack may not benefit from this research.
What this research studies
This research investigates the role of swelling, known as edema, that occurs in the heart after blood flow is restored following a blockage. It focuses on how this swelling contributes to heart damage and explores new ways to block the swelling without affecting blood vessel formation. By using specific drugs that target the swelling mechanism, the research aims to reduce heart damage and improve heart function in patients who have experienced a heart attack. Patients may benefit from new treatment strategies that could enhance recovery after such events.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that minimize heart damage and enhance recovery for patients after a heart attack.
How similar studies have gone: Previous research has shown promising results in targeting similar mechanisms of edema in other conditions, suggesting potential for success in this approach.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Simons, Michael — Yale University
- Study coordinator: Simons, Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.