Understanding Heart Rhythm Regulators
Functional interactions of cardiac ion channels
This work explores how tiny channels in heart cells, called SK channels, influence heart rhythms and heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-11180498 on NIH RePORTER |
What this research studies
Our hearts rely on electrical signals, and tiny channels in heart cells, called SK channels, play a key role in these signals. This project aims to better understand how these SK channels work in both healthy and diseased hearts. We know that SK channels are involved in heart rhythm problems like atrial fibrillation and are more active in heart failure, but we need to learn more about their exact role. By combining laboratory experiments and computer models, this work seeks to clarify how these channels contribute to heart conditions.
Who could benefit from this research
Good fit: Patients with heart rhythm disorders like atrial fibrillation or heart failure may eventually benefit from the discoveries made in this foundational research.
Not a fit: Patients seeking immediate treatment options will not directly benefit from this basic science research, as it focuses on fundamental understanding.
Why it matters
Potential benefit: If successful, this work could lead to new ways to treat common heart rhythm disorders and heart failure by targeting these specific channels.
How similar studies have performed: Previous studies have shown the important roles of SK channels in the heart, but there are still unanswered questions and seemingly conflicting findings that this project aims to resolve.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Chiamvimonvat, Nipavan — University of Arizona
- Study coordinator: Chiamvimonvat, Nipavan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.