Understanding Heart Rhythm Problems in TANGO2
Investigation of Cardiac Arrhythmias in TANGO2 Disorder
This project aims to understand why children with TANGO2 have dangerous heart rhythm problems and how B-vitamins might help.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11166559 on NIH RePORTER |
What this research studies
Children with TANGO2 disorder often experience severe heart rhythm issues that can be life-threatening and don't respond to typical medications. We believe that by understanding the underlying causes of these arrhythmias and how B-vitamins, particularly B9, might prevent or treat them, we can find better solutions. This work will involve studying patients already part of a natural history registry, as well as using special mouse models and human cells grown in the lab. Our goal is to uncover new ways to protect these children's hearts.
Who could benefit from this research
Good fit: Ideal candidates are young children, primarily 0-11 years old, diagnosed with TANGO2 Deficiency Disorder who experience recurring metabolic crises and ventricular arrhythmias.
Not a fit: Patients without TANGO2 Deficiency Disorder or those whose arrhythmias respond well to standard treatments would likely not receive direct benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new, effective treatments using B-vitamin supplementation to prevent and manage life-threatening heart arrhythmias in children with TANGO2 disorder.
How similar studies have performed: Promising data from an international patient registry and natural history study suggests that B-vitamin supplementation may prevent and treat arrhythmias in TANGO2 disorder.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Miyake, Christina Yumi — Baylor College of Medicine
- Study coordinator: Miyake, Christina Yumi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.