Understanding heart rhythm problems in a specific heart disease
Mechanisms of calcium-induced arrhythmias in arrhythmogenic right ventricular cardiomyopathy
This study is looking at how a genetic heart condition called arrhythmogenic right ventricular cardiomyopathy (ARVC) causes heart rhythm problems, using mice to learn more about how calcium affects heart cells, with the hope of finding new treatments that could help prevent serious issues for people with ARVC.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11002647 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind heart rhythm disturbances in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC), a genetic heart condition. By studying mice with a genetic mutation similar to that found in ARVC patients, the researchers aim to uncover how calcium handling in heart cells contributes to arrhythmias. The goal is to identify potential drug targets that could help prevent sudden cardiac death in affected individuals. Patients may benefit from insights gained into the early stages of ARVC and potential new treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with arrhythmogenic right ventricular cardiomyopathy or those with a family history of the condition.
Not a fit: Patients without arrhythmogenic right ventricular cardiomyopathy or those with other unrelated heart conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent life-threatening arrhythmias in patients with ARVC.
How similar studies have performed: Previous research has shown promising results in understanding calcium handling in heart diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Alvarado, Francisco J — University of Wisconsin-Madison
- Study coordinator: Alvarado, Francisco J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.