Understanding Heart Rhythm Problems and Calcium in Atrial Fibrillation
Atrial Excitation-Contraction Coupling, Calcium Signaling and Electro-Mechanical Alternans
['FUNDING_R01'] · RUSH UNIVERSITY MEDICAL CENTER · NIH-11118819
This research aims to better understand how calcium signals in heart cells contribute to irregular heartbeats, like atrial fibrillation.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUSH UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11118819 on ClinicalTrials.gov |
What this research studies
Our heart's upper chambers, called atria, have unique ways of handling calcium, which is crucial for every heartbeat. This project explores how calcium is released and managed within these atrial cells, especially focusing on a newly identified 'fire-diffuse-uptake-fire' mechanism. When this calcium handling goes awry, it can lead to beat-to-beat changes in heart activity, known as alternans, which are linked to serious rhythm problems like atrial fibrillation. We are also looking into how these processes might differ between sexes, as this can affect who is more prone to certain arrhythmias.
Who could benefit from this research
Good fit: This foundational research is for anyone interested in the underlying causes of atrial fibrillation and related heart rhythm disturbances.
Not a fit: Patients without atrial fibrillation or related heart rhythm conditions may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of atrial fibrillation, paving the way for new and more effective treatments for this common heart rhythm disorder.
How similar studies have performed: While the overall field of heart cell function is well-established, this project focuses on a newly identified mechanism and specific disturbances linked to arrhythmias, building on existing knowledge with novel insights.
Where this research is happening
CHICAGO, UNITED STATES
- RUSH UNIVERSITY MEDICAL CENTER — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BANACH, KATHRIN — RUSH UNIVERSITY MEDICAL CENTER
- Study coordinator: BANACH, KATHRIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.