Understanding heart rate changes to assess frailty in older adults with heart disease
Official title: Heart Rate Dynamics in Response to Upper-Extremity Function Test to Identify Irreversible Frailty After Invasive Therapy in Older Adults with Advanced Heart Disease
Funded at Rutgers Biomedical and Health Sciences · NIH-10763438 · Data updated 2026-11-12
This study is looking at how changes in heart rate can help doctors spot frailty in older adults with serious heart disease, especially those getting treatments like heart valve replacement, so they can better choose who is safe to undergo these procedures and improve their recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | January 15, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $283,450 |
| NIH project number | 5R01AG076774-03 |
| Project ID | NIH-10763438 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 65 and above who have advanced heart disease and are being considered for invasive therapies.
✕Less likely to help
Patients who are younger than 65 or those without advanced heart disease may not benefit from this research.
What this research studies
This research investigates how heart rate dynamics can help identify frailty in older adults suffering from advanced heart disease, particularly those undergoing invasive therapies like transcatheter aortic valve replacement (TAVR). By focusing on both motor and cardiac function, the study aims to create a quick and accurate frailty score that can be easily integrated into clinical practice. The goal is to improve the selection process for candidates who can safely tolerate aggressive treatments, thereby enhancing patient outcomes. The research utilizes a multidisciplinary approach, leveraging sensor-based assessments to gather objective data.
Why it matters
Potential benefit: If successful, this research could lead to better identification of frail patients, ensuring they receive appropriate care and treatment options tailored to their needs.
How similar studies have gone: While the approach of using heart rate dynamics for frailty assessment is innovative, similar methodologies in other contexts have shown promise, indicating potential for success.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Toosizadeh, Nima — Rutgers Biomedical and Health Sciences
- Study coordinator: Toosizadeh, Nima
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.