Understanding heart problems in patients with a genetic kidney disease
Mechanisms driving cardiac dysfunction in Autosomal Dominant Polycystic Kidney Disease
['FUNDING_R01'] · METHODIST HOSPITAL RESEARCH INSTITUTE · NIH-11061000
This study is looking at how heart problems can start in people with Autosomal Dominant Polycystic Kidney Disease (ADPKD) before kidney issues show up, focusing on a protein called Polycystin-1, to help find early signs and new ways to treat heart issues for those with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | METHODIST HOSPITAL RESEARCH INSTITUTE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11061000 on ClinicalTrials.gov |
What this research studies
This research investigates how heart dysfunction develops in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD), a condition that typically leads to kidney failure. The study focuses on the role of a specific protein, Polycystin-1, in heart cells and how its mutations may cause heart issues before kidney problems arise. By using mouse models that mimic human ADPKD, researchers will explore the cellular mechanisms behind heart dysfunction, aiming to identify early indicators and potential therapeutic targets. This approach could lead to better management strategies for patients with ADPKD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Autosomal Dominant Polycystic Kidney Disease, particularly those experiencing early signs of heart dysfunction.
Not a fit: Patients without a diagnosis of Autosomal Dominant Polycystic Kidney Disease or those with advanced kidney failure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and treatment of heart problems in ADPKD patients, improving their overall health outcomes.
How similar studies have performed: Previous research has indicated that cardiac dysfunction can occur independently of renal failure in ADPKD, suggesting that this approach is building on established findings rather than being entirely novel.
Where this research is happening
HOUSTON, UNITED STATES
- METHODIST HOSPITAL RESEARCH INSTITUTE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ALTAMIRANO, FRANCISCO — METHODIST HOSPITAL RESEARCH INSTITUTE
- Study coordinator: ALTAMIRANO, FRANCISCO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult Polycystic Kidney Disease