Understanding heart problems caused by frequent irregular heartbeats in pigs
Official title: Validation of Premature Ventricular Contraction-induced Cardiomyopathy on a Swine Model
Funded at VA Veterans Administration Hospital · NIH-10841501 · Data updated 2026-11-12
This study is looking at how frequent heartbeats called premature ventricular contractions (PVCs) can affect heart health, using pigs to help understand the problem better, which could eventually lead to improved treatments for people with similar heart issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Veterans Administration Hospital NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project start | July 1, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| NIH project number | 5I01BX004861-05 |
| Project ID | NIH-10841501 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing frequent premature ventricular contractions or related heart dysfunction.
✕Less likely to help
Patients with heart conditions unrelated to premature ventricular contractions may not benefit from this research.
What this research studies
This research investigates how frequent premature ventricular contractions (PVCs) can lead to heart dysfunction, specifically cardiomyopathy, using a swine model. The study aims to validate the presence of PVC-induced cardiomyopathy in pigs by examining their heart function and molecular changes. By comparing the swine model to previously studied canine models, researchers hope to uncover the cellular mechanisms behind this condition. Patients may benefit from insights gained about heart dysfunction related to PVCs, which could lead to better treatment options.
Why it matters
Potential benefit: If successful, this research could provide critical insights into heart dysfunction caused by irregular heartbeats, potentially leading to improved treatments for affected patients.
How similar studies have gone: While this approach is based on established models, the specific validation in swine is a novel investigation that has not been extensively tested.
Where this research is happening
-
VA Veterans Administration Hospital
Richmond, United States Active
Researchers
- Principal investigator: Huizar, Jose Francisco — VA Veterans Administration Hospital
- Study coordinator: Huizar, Jose Francisco
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.