Understanding heart problems caused by amyloid and cancer treatments
Official title: Elucidating Mechanisms of Cardiac Dysfunction Using Imaging and Proteomics
Funded at Brigham and Women's Hospital · NIH-10948811 · Data updated 2026-11-12
This study is looking at how heart problems happen in people with light-chain amyloid cardiomyopathy and those who have heart issues from cancer treatments, using special imaging and blood tests to find out which proteins might be causing these issues, so we can create better, personalized treatments for patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $106,978 |
| NIH project number | 1K99HL175107-01 |
| Project ID | NIH-10948811 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals diagnosed with light-chain amyloid cardiomyopathy or those experiencing cardiac dysfunction after receiving anthracycline chemotherapy.
✕Less likely to help
Patients with heart dysfunction not related to amyloidosis or cancer treatments may not benefit from this research.
What this research studies
This research investigates the mechanisms behind heart dysfunction in patients suffering from light-chain amyloid cardiomyopathy and those experiencing cardiac issues related to cancer treatments. By combining advanced cardiac imaging techniques with plasma proteomics, the study aims to identify specific proteins that may contribute to heart problems. This approach seeks to clarify why some patients develop severe cardiac dysfunction while others do not, potentially leading to more personalized treatment strategies. Patients may undergo imaging tests and provide blood samples to help researchers understand these complex interactions.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and treatment options for patients with heart dysfunction related to amyloidosis and cancer therapies.
How similar studies have gone: Previous research has shown promising results in using imaging and proteomics to understand cardiac dysfunction, indicating that this approach has potential for success.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Clerc, Olivier Florian — Brigham and Women's Hospital
- Study coordinator: Clerc, Olivier Florian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.