Understanding Heart Metabolism in Heart Failure
Probing the Role of Mitochondrial Short-chain Carbon Homeostasis in the Hypertrophied and Failing Heart
This work explores how the heart's energy use changes during heart failure to find new ways to help patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11328885 on NIH RePORTER |
What this research studies
Current treatments for heart failure often take a general approach, but there's a need for therapies that directly target the heart in its early stages. We know that as heart failure develops, the heart's ability to generate energy becomes disrupted, shifting from using fats to other fuels like sugar. This project aims to understand how these fuel changes are linked to the heart's declining energy function and the progression of heart failure. By identifying specific issues in how the heart processes fats, we hope to uncover new targets for treatments.
Who could benefit from this research
Good fit: This foundational research is for patients with heart failure, particularly those in early stages, as it seeks to understand the underlying metabolic changes in their hearts.
Not a fit: Patients without heart failure or those whose condition is not related to mitochondrial metabolic dysfunction may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new, targeted therapies that directly improve the heart's energy function and prevent the progression of heart failure.
How similar studies have performed: While the link between fuel shifts and mitochondrial dysfunction in heart failure has been observed, this project aims to establish a direct causal connection and identify specific bottlenecks, making its approach novel.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Muoio, Deborah M — Duke University
- Study coordinator: Muoio, Deborah M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.