Understanding heart injury caused by sepsis
Official title: Informing best practices for evaluation and treatment of myocardial injury during sepsis
Funded at Univ of Massachusetts Med Sch Worcester · NIH-10916493 · Data updated 2026-11-12
This study looks at how sepsis can harm the heart and aims to find the best ways to treat patients with this condition, especially by checking if blood thinners can help improve their recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | September 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $707,275 |
| NIH project number | 5R01HL169521-03 |
| Project ID | NIH-10916493 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with sepsis who also exhibit signs of myocardial injury.
✕Less likely to help
Patients who do not have sepsis or myocardial injury are unlikely to benefit from this research.
What this research studies
This research investigates how sepsis, a severe infection that can lead to organ dysfunction, affects the heart muscle, causing myocardial injury. It aims to identify the best practices for evaluating and treating patients with this condition by analyzing existing health records from large healthcare systems. The study will explore various treatment pathways and assess the effectiveness of blood thinners in improving outcomes for these patients. By gathering and analyzing this data, the research seeks to provide actionable insights for clinicians.
Why it matters
Potential benefit: If successful, this research could lead to improved evaluation and treatment strategies for patients suffering from myocardial injury during sepsis.
How similar studies have gone: Previous research has shown that analyzing electronic health records can effectively identify treatment patterns and improve patient outcomes in similar conditions.
Where this research is happening
-
Univ of Massachusetts Med Sch Worcester
Worcester, United States Active
Researchers
- Principal investigator: Walkey, Allan J. — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Walkey, Allan J.
Related research
Other NIH-funded projects on the same topics.
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Understanding how to care for heart injury during sepsis
This study looks at how doctors evaluate and treat heart injury that can happen when sepsis occurs, using real patient records to find better, more actionable care patterns.
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Improving care for heart injury during sepsis
This project aims to find better ways to understand and treat heart muscle injury that can happen when someone has sepsis.
-
Role of blood flow mechanics and transfusion in sepsis-related tiny-cl vessel clots
A patient-focused look at how red blood cell flow and transfusions might influence tiny blood vessel clots and organ problems in sepsis.
-
STeroids and enhanced Antibiotics for sepsis in Africa with HIV/TB (STARS)
This grant tests whether adding steroids and stronger antibiotics helps adults with severe sepsis tied to HIV/TB in areas with high TB rates.
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Steroids and better antibiotics for sepsis in people with AIDS in Africa
This study tests whether adding hydrocortisone and stronger antibiotics can improve survival for adults with sepsis who also have AIDS or advanced immune suppression in regions with high TB.
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Coordinating ARDS, Pneumonia, and Sepsis research to improve care
A national coordinating center helps researchers studying ARDS and related infections work together more efficiently to learn what helps patients recover.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.