Understanding heart health in survivors of blood stem cell transplants
Cardiovascular reserve capacity in survivors of hematopoietic cell transplantation
This study is looking at how heart health changes for people who have had a stem cell transplant, to better understand why they might face heart problems sooner than others, and it involves some tests to see how well their hearts are working before and after the transplant.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project ID | NIH-10782447 on NIH RePORTER |
What this research studies
This research investigates the cardiovascular health of individuals who have survived hematopoietic cell transplantation (HCT). It aims to understand how HCT affects heart function and the risk of cardiovascular diseases, which are more common and occur earlier in these patients compared to the general population. The study will measure cardiovascular reserve capacity using peak oxygen consumption tests at various time points before and after the transplant. By tracking these changes over time, the research seeks to uncover the biological mechanisms behind accelerated cardiovascular aging in HCT survivors.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have undergone hematopoietic cell transplantation.
Not a fit: Patients who have not undergone hematopoietic cell transplantation or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved monitoring and treatment strategies for cardiovascular issues in HCT survivors.
How similar studies have performed: Previous research has indicated that cardiovascular complications are a significant concern for HCT survivors, suggesting that this area of investigation is both relevant and necessary.
Where this research is happening
Duarte, United States
- Beckman Research Institute/city of Hope — Duarte, United States (Active)
Researchers
- Principal investigator: Armenian, Saro — Beckman Research Institute/city of Hope
- Study coordinator: Armenian, Saro
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.