Understanding heart function issues in young people with chronic kidney disease
Official title: Advancing the Approach to Subclinical Diastolic Dysfunction in Youth with Chronic Kidney Disease
Funded at Lurie Children's Hospital of Chicago · NIH-11037903 · Data updated 2026-11-12
This study is looking at how chronic kidney disease affects the hearts of young people and aims to find early signs of heart problems, while also testing if certain medications can help improve heart function.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lurie Children's Hospital of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | February 16, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $184,776 |
| NIH project number | 5K23DK138313-02 |
| Project ID | NIH-11037903 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are youth aged 0 to 21 years who have been diagnosed with chronic kidney disease.
✕Less likely to help
Patients without chronic kidney disease or those over the age of 21 may not benefit from this research.
What this research studies
This research investigates how chronic kidney disease (CKD) affects heart function in young patients, particularly focusing on subclinical diastolic dysfunction, which can lead to serious heart problems later in life. The study aims to identify early signs of heart issues using advanced echocardiographic techniques and to explore whether medications can help reverse these early changes. By applying patient-oriented research methods, the project seeks to improve the understanding and treatment of cardiovascular disease in youth with CKD.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for heart problems in young patients with chronic kidney disease.
How similar studies have gone: Previous research in adults with chronic kidney disease has shown promising results in understanding and treating cardiovascular issues, suggesting that this approach may also be beneficial in pediatric populations.
Where this research is happening
-
Lurie Children's Hospital of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Kula, Alexander James — Lurie Children's Hospital of Chicago
- Study coordinator: Kula, Alexander James
Related research
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-
Personalized CKD-MBD care using systems biology and AI
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This project tests a new way to prevent dangerous diabetic ketoacidosis in people with type 1 diabetes and chronic kidney disease who are using SGLT inhibitors, by tracking ketones in real time and combining glucose-keton data for safer therapy.
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Chronic Kidney Disease in Children: following young people as they grow up with CKD
A long-term study in kids with chronic kidney disease tracks kidney function and heart health as they transition into adulthood.
-
Chronic Kidney Disease in Children follow-up study
A long-term study that follows kids with kidney disease as they grow into young adults, collecting health data from home and official records.
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This grant looks at why some children who have malaria develop kidney injury and later chronic kidney disease, focusing on how severe malaria affects the kidneys over time.
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Boosting self-care and physical activity for older adults with chronic kidney disease
This program helps older adults with chronic kidney disease build the skills, confidence, and motivation to be more physically active.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.