Understanding heart failure with preserved ejection fraction through molecular analysis
Extraction of molecular signature of HFpEF via a machine learning-empowered proteomic characterization: A study of the BCAA pathway
This study is looking at heart failure with preserved ejection fraction (HFpEF) to understand how certain nutrients in the body, like branched-chain amino acids, might affect heart health, with the goal of finding better ways to diagnose and treat people living with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10440446 on NIH RePORTER |
What this research studies
This research investigates heart failure with preserved ejection fraction (HFpEF), a condition where patients experience heart failure symptoms despite having a normal ejection fraction. The study employs machine learning techniques to identify molecular signatures associated with HFpEF, particularly focusing on the role of branched-chain amino acids (BCAAs) and their metabolic pathways. By analyzing how these metabolic disruptions affect heart function at a cellular level, the research aims to develop better diagnostic criteria and treatment strategies for HFpEF patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with heart failure who have a preserved ejection fraction and are experiencing related symptoms.
Not a fit: Patients with heart failure and reduced ejection fraction (HFrEF) may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic methods and targeted therapies for patients suffering from HFpEF.
How similar studies have performed: Previous research has shown promising results in understanding metabolic pathways in heart failure, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Wang, Ding — University of California Los Angeles
- Study coordinator: Wang, Ding
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.