Understanding Heart Failure with Preserved Ejection Fraction (HFpEF)
Disruption of the Cardiac-Coronary Axis as a Mechanism of HFpEF
This research explores how problems with small blood vessels in the heart might cause a type of heart failure called HFpEF.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-11123996 on NIH RePORTER |
What this research studies
Heart failure with preserved ejection fraction (HFpEF) is a serious condition where the heart struggles to pump blood effectively, even though its main pumping chamber appears to work normally. We believe that issues with the tiny blood vessels in the heart, known as coronary microvascular dysfunction (CMD), play a crucial role in causing HFpEF. Our work aims to uncover the specific ways CMD leads to heart muscle damage and stiffness. We are particularly interested in a molecule called miR-21, which may help restore healthy blood flow in these small vessels. By studying these processes in a preclinical model, we hope to find new ways to help patients with HFpEF.
Who could benefit from this research
Good fit: This foundational research is relevant to adults diagnosed with heart failure with preserved ejection fraction (HFpEF).
Not a fit: Patients without HFpEF or those with other forms of heart failure may not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that target the underlying causes of HFpEF, improving heart function and quality of life for patients.
How similar studies have performed: Preliminary studies have validated the preclinical model used and shown promising ex vivo results regarding miR-21's role in coronary vasodilation.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Yin, Liya — University of Arizona
- Study coordinator: Yin, Liya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.