Understanding heart failure risks in women after preeclampsia through exercise testing
Official title: Identification of Early HFpEF after Preeclampsia by Exercise Stress Testing
Funded at Vanderbilt University Medical Center · NIH-10978719 · Data updated 2026-11-12
This study is looking at how having preeclampsia during pregnancy might affect heart health later on, especially the risk of heart failure, and it's for women who have had this condition to help find early signs and improve their heart care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | August 20, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $869,696 |
| NIH project number | 1R01HL170020-01A1 |
| Project ID | NIH-10978719 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women under 21 years old who have experienced preeclampsia during pregnancy.
✕Less likely to help
Patients who have not had preeclampsia or are over 21 years old may not benefit from this research.
What this research studies
This research investigates how preeclampsia, a pregnancy complication, may lead to long-term heart issues, specifically heart failure with preserved ejection fraction (HFpEF). By conducting exercise stress tests and analyzing various cardiovascular markers, the study aims to identify early signs of HFpEF in women who have experienced preeclampsia. The approach includes detailed assessments of heart function and structure, as well as biochemical changes, to better understand the risks these women face. The findings could help develop targeted interventions to improve heart health in this population.
Why it matters
Potential benefit: If successful, this research could lead to early identification and prevention strategies for heart failure in women who have had preeclampsia.
How similar studies have gone: Previous research has shown that understanding cardiovascular changes during and after pregnancy can lead to better health outcomes, suggesting this approach may yield valuable insights.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Lindley, Kathryn — Vanderbilt University Medical Center
- Study coordinator: Lindley, Kathryn
Related research
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A digital health approach uses AI to spot early warning signs of preeclampsia and gestational hypertension from pregnancy data, so clinicians can tailor care for pregnant people.
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Folate Receptor Beta and its Role in Preeclampsia
This study explores how a protein called folate receptor beta on placental immune cells may drive or worsen preeclampsia in pregnancy, with hopes of finding new ways to prevent or treat the condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.